HEALTH

Researcher confirms dementia and alzheimers are prostate cancer side effects of androgen deprivation therapy

Elderly men receiving 5 to 8 doses of androgen blockers developed either dementia or alzheimers in 10 years

Dr. Ravishankar Jayadevappa’s conclusive discovery that Lupron and other testosterone-blocking drugs cause dementia and Alzheimer’s provides men with the most important information they need in their treatment decisions and strategies.

WASHINGTON, D.C. – Elderly men diagnosed with prostate cancer should be discussing with their physicians and family the consequences of the now-confirmed reality that they’ll experience either dementia or alzheimer’s disease if more than 5 doses of testosterone-blocking hormones or orchiectomies are used to treat the life-shortening disease. 

This latest information was shared in the July 3, 2019 Journal of the American Medical Association (JAMA) from a researcher’s study of 154, 089 elderly men his team followed for 10 years after they received treatment within two years of a prostate cancer diagnosis.  University of Pennsylvania Perelman School of Medicine Research Associate Professor Ravishankar Jayadevappa concluded that deprivation therapy exposure was associated with subsequent diagnosis of Alzheimer disease or dementia over a follow-up period of at least 10 years.

Jayadevappa’s team of researchers set age limits to men 66 and older among the total of 295, 733 men they identified as having been newly-diagnosed with prostate cancer between 1996 and 2003.  The “sample” of men whose data the team evaluated was limited to the 154,089 they identified among the aged 66 and older men in the Surveillance, Epidemiology, and End Results (SEER) “fee for service” Medicare Database. 

The analyses of the data was conducted between November 1, 2018, and December 31, 2018.   The team observed that the National Cancer Institute’s SEER regions have a higher proportion of nonwhite individuals. 

Jayadevappa and his team concluded that “clinicians must carefully weigh the long-term risks and benefits of exposure to androgen deprivation therapy in patients with a prolonged life-expectancies.” 

Eric Jonathan Brewer
Cleveland's most influential journalist and East Cleveland's most successful mayor is an East Saint Louis, Illinois native whose father led the city's petition drive in 1969 to elect the first black mayor in 1971. Eric is an old-school investigative reporter whose 40-year body of editorial work has been demonstrably effective. No local journalist is feared or respected more. Trained in newspaper publishing by the legendary Call & Post Publisher William Otis Walker in 1978 when it was the nation's 5th largest Black-owned publication, Eric has published and edited 13 local, regional and statewide publications across Ohio. Adding to his publishing and reporting resume is Eric's career in government. Eric served as the city's highest paid part-time Special Assistant to ex-Cleveland Mayor Michael R. White. He served as Chief of Staff to ex-East Cleveland Mayor Emmanuel Onunwor; and Chief of Communications to the late George James in his capacity as the Cuyahoga Metropolitan Housing Authority's first Black executive director. Eric was appointed to serve as a member of the state's Financial Planning & Supervision Commission to guide the East Cleveland school district out of fiscal emergency and $20 million deficit. Former U.S. HUD Secretary Alphonso Jackson told Eric in his D.C. office he was the only mayor in the nation simultaneously-managing a municipal block grant program. Eric wrote the city's $2.2 million Neighborhood Stabilization Program grant application. A HUD Inspector General audit of his management of the block grant program resulted in "zero" audit findings. As a newspaper publisher, Eric has used his insider's detailed knowledge of government and his publications to lead the FBI and state prosecutors to investigations that resulted in criminal prosecutions of well-known elected officials in Ohio; and have helped realign Cleveland's political landscape with the defeat of candidates and issues he's exposed. Eric's stories led to the indictments of the late Governor George Voinovich's brother, Paul Voinovich of the V Group, and four associates. He asked the FBI to investigate the mayor he'd served as chief of staff for public corruption; and testified in three federal trials for the prosecution. He forced former Cuyahoga County Coroner Dr. Elizabeth Balraj to admit her investigations of police killings were fraudulent; and to issue notices to local police that her investigators would control police killing investigations. Eric's current work has resulted in Cuyahoga County Judge John Russo accepting the criminal complaint he guided an activist to file against 24 civil rights-violating police officers in the city he once led for operating without valid peace officer credentials. USA Today reporters picked up on Eric's police credentials reporting from his social media page and made it national. Eric is the author of of his first book, "Fight Police License Plate Spying," which examines the FBI and local police misuse of the National Crime Information Center criminal records history database. An accomplished trumpet player and singer whose friendship with Duke Fakir of the Four Tops resulted in his singing the show's closing song, "Can't Help Myself": Curtis Sliwa of New York's Guardian Angels counts Eric among his founding chapter leaders from the early 1980's role as an Ohio organizer of over 300 volunteer crime fighters in Cleveland, Columbus and Youngstown, Ohio. For his work as a young man Eric was recognized by Cleveland's Urban League as it's 1983 Young Man of the Year. Known in Cleveland for his encyclopedic knowledge of government and history, and intimately-connected with the region's players, every local major media outlet in Cleveland has picked up on one of Eric's stories since 1979. There is no mainstream newspaper, television or radio outlet in Cleveland that does not include an interview with Eric Jonathan Brewer in its archives over the past 40 years.

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